Chiang Mai Journal of Science

Three New Polycyclic Containing Sulfur Compounds from the Seeds of Combretum quadrangulare Kurz (Combretaceae), Antifungal and Anti-mycobacterium activities

Paper Type	Contributed Paper
Title	Three New Polycyclic Containing Sulfur Compounds from the Seeds of Combretum quadrangulare Kurz (Combretaceae), Antifungal and Anti-mycobacterium activities
Author	Khesorn Nantachit*, Sasithorn Sirilun, Saksit Nobsathian and Somjing Rungjang
Email	khesornn@gmail.com
Abstract: Three new polycyclic containing sulfur compounds, Combretanoid, Combretanane and Combretanun, were isolated. The crude ethanolic extract and pure compound Combretin, the isolated pure compound from the seeds of Combretum quadrangulare Kurz (Combretaceae), showed antimicrobial activities against many pathogens. The aim of this study was to determine antifungal activity against opportunistic pathogens in HIV patients and anti-mycobacterium tuberculosis activity (anti-TB). An Antifungal test was performed by agar dilution method and an anti-TB test was done using green fluorescent protein microplate assay (GFPMA). Crude ethanolic extract from Amphur Sun Srai showed antifungal activity against A. fumigatus better than the extract from Amphur Sarapee. Combretanoid showed no antifungal activity and the three new compounds showed no anti-TB activity. This plant showed no toxicity to albino rat and mice. In conclusion, it may used as a traditional method for antifungal activity against A. fumigatus.
Start & End Page	157 - 167
Received Date	2015-03-23
Revised Date
Accepted Date	2015-08-18
Full Text	Download
Keyword	Combretanoid, Combretanane, Combretanun, Antifungal, Anti-mycobacterium activities
Volume	Vol.44 No.1 (JANUARY 2017)
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