Stability of Vancomycin 31 mg/mL in Extemporaneous Eye Drops Determined with Capillary Electrophoresis
Anutra Khangtragool, Sineenart Santidherakul and Phuriwat Leesawat* Author for corresponding; e-mail address: akhangtr@med.cmu.ac.th
Volume :Vol.38 No.4 (OCTOBER 2011)
Research Article
DOI:
Received: -, Revised: -, Accepted: -, Published: -
Citation: Khangtragool A., Santidherakul S. and Leesawat P.., Stability of Vancomycin 31 mg/mL in Extemporaneous Eye Drops Determined with Capillary Electrophoresis, Chiang Mai Journal of Science, 2011; 38(4): 533-540.
Abstract
This study evaluates the stability of extemporaneous ophthalmic antibiotic preparations made from a commercially available injection of vancomycin of 31 mg/mL and stored at 2-8°C and 28°C for 3 months. After various storage times, the stability was determined by capillary electrophoresis. Solutions of vancomycin 31 mg/mL in Tear Naturale ПTM were found to be stable after storage at 2-8°C and 28°C for 28 days, respectively. Vancomycin 31 mg/mL in extemporaneous eye drops prepared and supplied by a pharmacy should be stored at 2-8°C for less than 28 days.