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Stability of Vancomycin 31 mg/mL in Extemporaneous Eye Drops Determined with Capillary Electrophoresis


Paper Type 
Contributed Paper
Title 
Stability of Vancomycin 31 mg/mL in Extemporaneous Eye Drops Determined with Capillary Electrophoresis
Author 
Anutra Khangtragool, Sineenart Santidherakul and Phuriwat Leesawat
Email 
akhangtr@med.cmu.ac.th
Abstract:

This  study  evaluates  the  stability  of  extemporaneous  ophthalmic  antibiotic  preparations  made  from  a  commercially  available  injection  of  vancomycin  of  31  mg/mL  and  stored  at  2-8°C  and  28°C  for  3  months. After  various  storage  times, the  stability  was  determined  by  capillary  electrophoresis. Solutions  of  vancomycin  31  mg/mL  in  Tear  Naturale  ПTM  were  found  to  be  stable  after  storage  at  2-8°C  and  28°C  for  28  days, respectively. Vancomycin  31  mg/mL  in  extemporaneous  eye  drops  prepared  and  supplied  by  a pharmacy  should  be  stored  at  2-8°C  for  less  than  28  days.

Start & End Page 
533 - 540
Received Date 
Revised Date 
Accepted Date 
Full Text 
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Keyword 
extemporaneous eye drops, stability, vancomycin, capillary electrophoresis
Volume 
Vol.38 No.4 (OCTOBER 2011)
DOI 
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Chiang Mai Journal of Science

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