Stability of Vancomycin 31 mg/mL in Extemporaneous Eye Drops Determined with Capillary Electrophoresis

Anutra Khangtragool, Sineenart Santidherakul and Phuriwat Leesawat
* Author for corresponding; e-mail address: akhangtr@med.cmu.ac.th
Volume: Vol.38 No.4 (OCTOBER 2011)
Research Article
DOI:
Received: -, Revised: -, Accepted: -, Published: -

Citation: Khangtragool A., Santidherakul S. and Leesawat P.., Stability of Vancomycin 31 mg/mL in Extemporaneous Eye Drops Determined with Capillary Electrophoresis, Chiang Mai Journal of Science, 2011; 38(4): 533-540.

Abstract

This study evaluates the stability of extemporaneous ophthalmic antibiotic preparations made from a commercially available injection of vancomycin of 31 mg/mL and stored at 2-8°C and 28°C for 3 months. After various storage times, the stability was determined by capillary electrophoresis. Solutions of vancomycin 31 mg/mL in Tear Naturale П^TM were found to be stable after storage at 2-8°C and 28°C for 28 days, respectively. Vancomycin 31 mg/mL in extemporaneous eye drops prepared and supplied by a pharmacy should be stored at 2-8°C for less than 28 days.

Keywords: extemporaneous eye drops, stability, vancomycin, capillary electrophoresis

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Chiang Mai Journal of Science

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