Paper Type |
Contributed Paper |
Title |
Petasites japonicus Ethanol Extract Inhibited Collagen-Induced Platelet Aggregation and Thrombus Formation in Rats |
Author |
Hyun Dong Ji [a], Taddesse Yayeh [a], Ji Young Park [a], Sung Dae Kim [a], Eun Ju Im [a], Young Min |
Email |
rheemh@knu.ac.kr |
Abstract: Petasites japonicas (P. japonicas), a perennial plant of Asteraceae family, has been reported for antioxidant, anti-obesity and anti-allergic effects. However, the anti-platelet and anti-thrombotic activities of this plant were remained unclear. Therefore, this study aimed to portray the anti-platelet and anti-thrombotic properties of P. japonicas ethanol extract (PJET) in rats. PJET (31 -500 μg/ml) impaired in vitro collagen-stimulated platelet aggregation, [Ca2+]i mobilization and ATP secretion dose dependently. Moreover, PJET attenuated p38 mitogen-activated protein kinase, c-Jun N-terminal kinase 1 (JNK1) and extracellular-signal-regulated protein kinase 2 (ERK2) protein phosphorylations. Likewise, PJET diminished thrombus formation in extracorporeal shunt model. In conclusion, PJET could be a source of potential natural compounds that reduce disseminated intravascular platelet aggregation and thrombus formation.
|
|
Start & End Page |
360 - 369 |
Received Date |
2012-08-09 |
Revised Date |
|
Accepted Date |
2013-02-18 |
Full Text |
Download |
Keyword |
|
Volume |
Vol.41 No.2 (APRIL 2014) |
DOI |
|
Citation |
Ji H.D., Yayeh T., Park J.Y., Kim S.D., Im E.J. and Min Y., Petasites japonicus Ethanol Extract Inhibited Collagen-Induced Platelet Aggregation and Thrombus Formation in Rats, Chiang Mai J. Sci., 2014; 41(2): 360-369. |
SDGs |
|
View:477 Download:164 |