Chiang Mai Journal of Science

Methocel E4M: Preparation and Properties as a Vehicle for the Ocular Drug Delivery of Vancomycin

Paper Type	Contributed Paper
Title	Methocel E4M: Preparation and Properties as a Vehicle for the Ocular Drug Delivery of Vancomycin
Author	Anutra Khangtragool
Email	akhangtr@mail.med.cmu.ac.th
Abstract:  In this study, hydroxypropyl methylcellulose (HPMC, MethocelTM E4M) was chosen in 0.3% and 0.4% w/v concentrations at pH 7.1 as an ocular drug delivery vehicle for vancomycin and its in vitro characteristics and stability determined. The viscosity, osmolality, clarity, pH and contamination of each of the formulations were determined. From stability assessments, MethocelTM E4M 0.3% and 0.4% w/v pH 7.1 could be stored at 2-8 °C and 30 °C for 360 days. Osmolalities and pH were acceptable for use in the eyes. No contamination was found in both 0.3% and 0.4% w/v MethocelTM E4M pH 7.1. All solutions remained clear throughout the study. The kinematic viscosity of MethocelTM E4M 0.3% w/v relative to artificial tears indicated that it was suitable for the ocular drug delivery of vancomycin 50 mg/ml.
Start & End Page	166 - 173
Received Date	2012-11-22
Revised Date
Accepted Date	2013-04-15
Full Text	Download
Keyword
Volume	Vol.41 No.1 (JANUARY 2014)
DOI
SDGs
View:472 Download:263