Chiang Mai Journal of Science

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A new method for heterogeneous nucleophilic scavenging with silica supported dichlorotriazine (Si-DCT, 2) is described. The Si-DCT was prepared by immobilized commercial grade silica gel with 3-aminopropyltrimethoxysilane, followed by reacting with cyanuric chloride. The applications of Si-DCT in removal of unwanted nucleophilic impurities from reaction mixture were demonstrated. It was shown that excess amines from sulfonamide and amide syntheses can be completely removed by adding Si-DCT and filtering off the solid. The desired products were obtained in high yields and purities without any further purification steps.

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